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Using the selection of UPR-regulated mRNAs in Figure 1A as a broad indicator of ER stress signaling, we found that etomoxir also diminished UPR activation in C2C12 myoblasts (Figure 1D), and immortalized (data not shown) and primary (Figure 1E) brown adipocytes

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In addition, the disruption of soils from mining and large-scale farming has uprooted many natural endocrine disruptors