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In contrast, Th1/Th17 cells, effector memory CD8 T cells, and mucosal-associated invariant T cells (MAIT cells) are enriched in gout patients joint fluids ( Imbalance of Th1 and Th2 Excessive purines dont directly enhance XOR expression in human hepatocytes

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Oncogene 22 , 73697375 (2003)

Proposed mechanisms include NO-related preservation of microvascular function, indirect modulation of neurotransmitter systems, and possible brain-gut-axis involvement

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Limitations This was a pilot study to determine whether this novel glutathione formulation could increase GSH and GSSG in the blood, thus there are some intrinsic limitations to this type of study