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Inactivation of the Hippo tumor suppressor pathway promotes melanoma
Preclinical research in murine senescence models has examined FOXO4-DRI for its capacity to reduce senescent cell burden, with observed improvements in physical function, coat density, and renal histology endpoints in aged subjects
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This approach aligns with the goals of a systematic review into a novel research area, where the primary aim is to gather and describe existing knowledge rather than to rigorously assess study quality or synthesize outcomes quantitatively
