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The review is the first to compare efficacy of the three FDA-approved GLP-1 medications in non-diabetic patients using the drugs for weight loss

Here is what we do not know

Key genetic variants such as FTO rs9939609 and MC4R rs17782313 influence metabolic rate and appetite signaling

In most cases, resistance training is encouraged if there are no medical contraindications

Bydureon kept exenatide relevant as newer GLP-1 drugs emerged, but eventually exenatides role diminished since newer agents offered even greater efficacy