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The absolute contraindications (thyroid cancer history, MEN2) are rare conditions
The triple agonism is achieved through a combination of conserved interactions and receptor-specific contacts within the transmembrane domain
Phenobarbital should generally be avoided in any patient with a history of hepatic encephalopathy
They stimulate insulin secretion from the pancreas in a glucose-dependent manner, meaning they promote insulin release only when blood sugar levels are elevated, which reduces the risk of hypoglycemia
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