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10.2337/db08-0792 35 HolmanR

Alongside these, several studies focused on elucidating the role of mitogen-activated protein kinases (MAPKs) in NRF2 activation, suggested the involvement of c-jun N-terminal kinase 1/2 (JNK1/2) and extracellular signal-regulated kinase 1/2 (ERK1/2) in the NRF2 activation and nuclear accumulation [208, 209]

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The highest tissue concentrations of free lipoic acid likely to be achieved through oral supplementation are at least 10 times lower than those of other intracellular antioxidants, such as vitamin C and glutathione

*Aravinda Jayasundara, 1 Nalini Abeysekera *Associate Professor, Ocean University of Sri Lanka, Faculty of Pharmaceutical Sciences 1 Assistant Professor, Ocean University of Sri Lanka, Faculty of Pharmaceutical Sciences Article Details Title: Exploring the Role of the Pentose Phosphate Pathway in Macrophage Function Authors: Aravinda Jayasundara, Nalini Abeysekera Published in: PEXACY International Journal of Pharmaceutical Science Volume/Issue: 2(12) Pages: 262-275 Publication Date: 20/12/2023 ISSN: 2584-024X Language: English Publisher: PEXACY International Journal of Pharmaceutical Science PDF Download: Access Full Paper Abstract: This article focus into the pentose phosphate pathway in macrophages, highlighting its critical role in cellular metabolism and immune response