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Studies have also examined its potential influence on angiogenesis, fibroblast signaling, and nitric oxide related pathways
In laboratory research settings, GHK-Cu has been investigated for its effects on fibroblast gene expression profiles, collagen and glycosaminoglycan synthesis characterization in cell culture models, and antioxidant enzyme upregulation via Nrf2 pathway activation
In endothelial cell models, BPC-157 significantly enhanced ERK1/2 phosphorylation in a dose-dependent manner, leading to increased cellular proliferation, migration, and vascular tube formation