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We estimate that people who are homozygous for the risk alleles at both the GLP1R and GIPR loci have a 14.8-fold increased odds (95% confidence interval [6.2, 35.8]) of tirzepatide-mediated vomiting, compared with those homozygous for the non-risk alleles

When used with insulin or sulfonylureas, there is an increased risk of hypoglycaemia, and doses of these medications may need adjustment

E-EL-0058), respectively

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The IAPAM does not recommend the use of any agent outside of the labeled indications