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The table shows cyanocobalamin is effective and affordable, but hydroxocobalamin lasts longer

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As well, some people may have allergies or medical conditions that do not allow them to be a good candidate to receive vitamin B12 shots, such as kidney problems, low potassium levels, deficiencies in other vitamins such as iron or folic acid, or just an allergy or sensitivity to vitamin B12 itself

Researchers at higher maintenance doses often prefer 20mg vials because they last longer and reduce the frequency of reconstitution