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& Sanflix-Gimeno, G

Additional evidence for a specific role of sst 2 receptor came from the observation that a stressful experience is associated with an increase of sst 2 mRNA levels within the amygdala (Nanda et al., 2008) and that mice lacking sst 2 receptor display increased anxiety-like behaviors associated with increased pituitary ACTH levels, a main regulator of the stress response (Viollet et al., 2000)

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These effects may be connected to modulation of growth hormone and IGF-1 signaling, as well as alterations in hepatic urea cycle enzyme activity