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Injectable evidence is mostly preclinical with strong mechanism data, plus community use
Analysis of labeled BCAAs metabolites showed more labeled -Ketoisocaproate (-KIC) and Leu-derived BCKAs in NSCLC cells
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In the gastrointestinal system , these medications slow gastric emptying and reduce appetite through central nervous system pathways, contributing to weight loss
On the contrary, Acetyl-CoA is an activator of pyruvate carboxylase, thus promoting the TCA flux or the gluconeogenesis (Pietrocola et al., 2015)
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