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Beyond nausea, the gastrointestinal side effect cluster includes diarrhea, vomiting, constipation, and decreased appetite, which is technically a desired effect but can become problematic at extreme levels

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Preclinical investigations have explored BPC-157 in experimental models studying: tendon and ligament repair pathways skeletal muscle regeneration signaling angiogenesis and vascular growth responses gastrointestinal mucosal protection inflammatory signaling pathways Experimental studies examining soft-tissue injury models have reported that BPC-157 may influence microvascular circulation and growth-factor signaling associated with tissue repair processes

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10.3389/fpubh.2022.801619 Summary Keywords inhalation risk assessment, lung exposure modelling, lung toxicity, new approach methodologies, nonanimal testing, point of departure, bioactivity exposure ratio Citation de vila RI, Mller I, Barlow H, Middleton AM, Theiventhran M, Basili D, Bowden AM, Saib O, Engi P, Pietrenko T, Wallace J, Boda B, Constant S, Behrsing HP, Patel V and Baltazar MT (2025) Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety