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Anitha (Yarandi et al., 2020), and their colleagues noticed that TLR2- and TLR4-deficient mice align with the mechanism responsible for gut dysmotility in germ-free mice, characterized by a diminished quantity of nitrergic inhibitory neurons

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To restore the right balance, make sure you eat plenty of highly-coloured fruits and vegetables (colour = high antioxidant content), reduce your exposure to pollutants , get enough sleep and minimise any sources of stress