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Conversely, at higher concentrations (5-10 M) or in melanocytes with elevated baseline melanogenic activity, GHK-Cu can suppress tyrosinase activity and reduce melanin production by 20-40%, offering potential benefits in melasma or post-inflammatory hyperpigmentation

But its not a miracle cure, and there is no substantial data on its impact on thinning hair, nor great studies on systemic use for weight gainbenefits touted by some without much evidence

Mulder et al., Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-l-histidyl-l-lysine copper, Wound Repair Regen

Competing interests All authors declare that they have no commercial or other associations that may pose a conflict of interest

In practice, [hydroquinone] compounded up to 8% is considered to be high and is only recommended for short periods of time, says Lesley Clark-Loeser, MD, a board-certified dermatologist in Davie, Florida