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It greatly influences bone density

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In the phase 2 trial, the 8mg group achieved approximately 17.3% weight reduction at 24 weeks, a rate of loss that would not be possible without profound appetite suppression driving significant caloric deficit

Kugler, C

This is particularly relevant because visceral fat drives inflammation, insulin resistance, fatty liver disease, and long-term cardiovascular risk

Myostatin, and related ligands, signal through the Activin receptor to repress muscle hypertrophy