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The GLP-1 receptor agonist class does not appear to produce lasting receptor downregulation after washout, making transition protocols feasible in research settings
But most information online is based on Western bodies
The Science: GLP-1 Drugs, Cartilage, and Bone Health Are More Intertwined Than Anyone Expected The most exciting recent finding comes out of Cell Metabolism, where researchers showed that semaglutide may directly reverse cartilage damage in osteoarthritis, and here is the key part: that benefit appears to be independent of weight loss
It also helps relieve or prevent fatigue and may reduce histamine release, aiding in allergy prevention
Fourman LT, Czerwonka N, Feldpausch MN, et al
You may not be losing weight on semaglutide because your body has adapted, your calorie needs have changed, muscle mass has declined or underlying medical factors are affecting progress
