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Cell Survival and Proliferation: GLP-1 signaling activates the PI3K/Akt pathway, which promotes -cell survival by inhibiting apoptotic signals (such as caspase activation) and enhancing proliferation (Zheng et al., 2024)
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GLP-1 delays gastric emptying via stimulating inhibitory nitrergic myenteric neurons [18] and activating vagal afferents [19], leading to reduced gastrointestinal motility [20]
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Similarly, soluble fiber from oats, beans, and vegetables stimulates L-cells to produce more GLP-1, which explains why high-fiber diets often support weight management
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