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Classical exhaustion is typically driven by prolonged antigenic stimulation and is characterized by progressive loss of effector function, sustained expression of multiple inhibitory receptors (including programmed cell death protein 1, PD-1), andcriticallya stable exhaustion-associated epigenetic landscape that constrains reinvigoration even after checkpoint blockade ( A key unresolved question is whether perioperative immune dysfunction engages the core transcriptional circuitry of exhaustion

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Consume sulfur-rich foods like garlic, onions, and cruciferous vegetables, which provide raw materials for Glutathione synthesis

It remains unclear how this would change after longer periods of observation or repeated exposure

"Diet and male (in)fertility." J Clin Med 2020;9:1400

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