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Its difficult to distinguish direct anti-inflammatory effects from the benefits of weight loss and improved metabolic health, but the pattern is consistent enough to warrant further study. A 2025 study found that RA patients with a BMI over 27 taking GLP-1 medications showed improvements in symptoms and disease activity

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For athletes, this can be a major setback, often leading to changes in their training schedule and wasted time that could be better spent improving their fitness

The starting dose is designed for tolerance assessment, not therapeutic effect

The hypothalamus is particularly sensitive to energy availability and metabolic signals

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