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Previous antiobesity medications showed modest efficacy with limited long-term safety data and limited benefits beyond weight loss

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The 80% increase in dentate gyrus neurogenesis and the reversal of dendritic and synaptic density loss make P21 particularly suited to the recovery phase, where the goal is not preventing further damage but restoring function

Karandikar R, Badri A, Phale PS (2015) Biochemical characterization of inducible Reductase component of benzoate dioxygenase and phthalate isomer dioxygenases from Pseudomonas aeruginosa strain PP4

For small peptides this can help somewhat, but the data is thin

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