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In one clinical trial, 5 mg per week tirzepatide was slightly more effective than 1 mg per week semaglutide in reducing body weight and glycated hemoglobin (HbA1c)

Even small differences in peptide quality, solubility, degradation, or contamination can affect cell-based assays

Macrophage-derived exosomes enriched in ferroptosis-inhibitory microRNAs, such as miR-485-5p or miR-214-3p, or exogenously engineered vesicles delivering FSP1, represent promising cell-specific delivery platforms (157, 188, 199, 200)

At the same time, multiple blockbuster GLP-1 therapies are already on the market (Ozempic, Wegovy, and Mounjaro), with numerous next-generation analogues and combination incretin therapies currently in development

Maihemuti A, Cui C, Wang Q, Amuti R, Chau WW, Chai S, Zhang N, Wong RMY, Ko H, Kwok TC, Cheung WH

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