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Oral semaglutide is taken once daily and reduces HbA 1c levels to a significantly higher extent than DPP-4 inhibition or sodiumglucose cotransporter 2 (SGLT-2) inhibition and to a similar extent as liraglutide, whereas body weight is reduced by a significantly higher extent than by DPP-4 inhibition and liraglutide and to a similar extent as SGLT-2 inhibition [30, 31]

As semaglutide suppresses appetite and causes gastrointestinal side effects such as diarrhea and vomiting, the medication may lead to dehydration, resulting in headaches

The analysis published in 2019 used a slightly different dataset, based on the intent-to-treat population in which missing data were imputed using multiple imputation based on retrieved dropout analysis [15]

Sandforth, A