semaglutide review article Frontiers A systematic review and meta-analysis

PMID: 23794943

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Among GLP-1 users, 59% reported at least one impact of the drug on their dating life, including: 17% purchased new clothing to show off their body 16% said they heard from exes or former partners who wanted to reconnect 14% said they were getting more matches on dating apps 13% felt more confident posting photos of themselves online 12% felt more confident asking other people out 12% said they were going on more dates

The consequences of excessive lean mass loss include: Reduced resting metabolic rate muscle is metabolically active tissue, so losing it lowers the number of calories your body burns at rest Impaired physical function particularly concerning in older adults, where sarcopenia (age-related muscle loss) is already a risk Potential for weight regain a lower metabolic rate after weight loss can create conditions favorable for regaining weight if the drug is stopped Bone density reduction significant weight loss can also reduce bone mineral density, increasing fracture risk What we know from other GLP-1 drugs For context, the "ideal" ratio is debated, but most clinicians consider it acceptable if lean mass loss accounts for less than ~25% of total weight lost

If Barbie the movie wants you to embrace the old woman at the bus stop, lots of women watched it and came away with the desire to inject Botox into their shoulders until their muscles shrank away

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