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Weight loss during this phase typically averages 1.5-2.5 lbs weekly, with the majority coming from fat stores

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Researchers may investigate its role in maintaining cellular redox balance, supporting enzymatic activity, and influencing molecular interactions within experimental models

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The GLP-1R and GIPR pathways both converge on beta cell function through incretin signaling, and retatrutide provides a tool to study the amplified incretin response that occurs when both receptors are activated simultaneously