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Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix

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doi: 10.1038/s41538-024-00253-2 15 BrettleH.TranV.DrummondG

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Particles can form from peptide crystallization out of solution, which happens when the formulation is frozen, contamination during the reconstitution or drawing process, degradation products that have precipitated out of solution, or incompatibility between the tirzepatide and the vial or stopper material

GLP-1 agonist drugs are most often used to help type 2 diabetes patients lower their blood sugars or to help patients with heart disease prevent heart attacks or strokes, but some also can help treat obesity and soon could be approved for sleep apnea and other treatments