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Additional approaches under investigation include Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-targeted genome editing in human induced pluripotent stem cell-derived hepatocytes [139]

Each experiment was independently repeated three times and data is presented as mean plus or minus standard deviation unless otherwise noted

While formal drug interaction studies are limited, AOD-9604 can often be safely combined with other therapies under proper medical supervision

Availability of data and materials No datasets were generated or analysed during the current study

Dual use The dual use of e-cigarettes and traditional combustible cigarettes, a pattern increasingly observed worldwide, poses compounded risks for metabolic and liver health [138, 139]

Unlike appetite suppressants where weight often rebounds quickly, 5-amino-1MQ works by improving metabolic efficiency