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Studies have shown reductions in markers such as C-reactive protein and other indicators of systemic inflammation in some people treated with GLP-1 receptor agonists

However, the strength and limitations of the available evidence (e.g., cross-sectional vs

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[33] [34] In 2026, the UK Medicines and Healthcare products Regulatory Agency (MHRA) updated its guidance on GLP-1 medication after an increase in reports to the agency's Yellow Card Scheme of acute pancreatitis, with fatalities, in patients taking semaglutide or tirzepatide, to warn of a small risk of developing severe acute pancreatitis

Phase 2 studies demonstrated that twice-daily exenatide injections significantly lowered blood glucose levels and hemoglobin A1c , with many patients achieving better glycemic control than with oral medications alone ( [58] ) ( [2] )