Moses RG, Kalra S, Brook D et al (2014) A randomized controlled trial of the efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes and inadequate glycaemic control on metformin plus a sulphonylurea
Start your intake Tirzepatide as a dual-incretin molecule Tirzepatide is a GIP and GLP-1 dual agonist, distinct from single GLP-1 receptor agonists because it engages two incretin pathways rather than one
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These two effectors of cAMP signaling modify several targets within the secretory machinery, with the net effect to synergistically enhance the amount of insulin secreted in response to glucose stimulation (15, 16)