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After 72 weeks, participants taking 7.2mg lost an average of 18.7% of their starting body weight, compared with 3.9% in the placebo group
Rotate injection sites every administration, using a different quadrant of the abdomen or switching between abdomen, lateral thigh, and outer arm to prevent localized tissue irritation
No clinical differences between the groups could explain the different responses in the MMTT to the same stimulus
However, rapid pharmacologically induced weight loss may be accompanied by unfavorable body-composition changes, including reductions in lean mass, and weight regain is common following treatment discontinuation, underscoring a major durability gap
Lean mass preservation requires active management
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