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The resulting hormonal shift naturally suppresses appetite for many patients
In Phase 2 trials, retatrutide produced average weight loss of up to 24% at the highest dose over 48 weeks substantially above tirzepatide's 2022% in equivalent trial conditions
For Providers: A Novel Tool for Your Practice We believe this combination represents a meaningful step forward in personalized metabolic care
A registry study in 2020 in the US showed only 40% of the patients with CKD were on ACEi/ ARBs, and smaller similar percentages (around 6%) for SGLT2i and GLP1-RA use (Nicholas, et al, Diabetes Obes Metab, 2023)
Puumala et al., 2024
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