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doi:10.2337/dc19-2046 Giacco F, Brownlee M
In 2025, several major studies began to connect GLP-1 therapy to healthier aging
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This increases the concentration of malonyl-CoA, the first intermediate in fatty acid synthesis, leading to the inhibition of carnitine acyltransferase 1, thereby preventing fatty acid entry into the mitochondrial matrix for oxidation
The majority of the time, free radicals are a byproduct of waste that healthy cells, and toxic overload from unhealthy cells
For context, some of the GLP-1 weight loss drugs can be prescribed for reasons other than weight loss
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