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The formal pharmacokinetic data showing a 33% increase in levothyroxine exposure was studied with oral semaglutide specifically, but injectable formulations of both drugs also slow gastric emptying enough to affect thyroid medication absorption
Pharmacologically this yields a highly selective GHS-R1a agonist which, in classical rodent studies (Raun et al., Eur J Endocrinol 1998), does not significantly elevate cortisolemia, ACTH, prolactin or FSH/LH at effective doses, unlike GHRP-2 and GHRP-6
Medical care is essential if symptoms develop, but dietary changes, such as eliminating gluten, reducing intake of iodine-rich foods, and adding selenium-rich foods, may help support thyroid function and hormone balance
It also promotes satiety, or a feeling of fullness
Crepel F, Mariani J, Delhaye-Bouchaud N (1976) Evidence for a multiple innervation of Purkinje cells by climbing fibers in the immature rat cerebellum
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