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The gut microbiota may be interacting with the other pathways such as inflammation, or endocrine which then interact with and affect the integrity of the BBB, but either way it is now apparent that the gut microbiota is a modulator of BBB integrity

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[7] Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene

Therapeutic targeting of peripheral immune pathways in PD: current advances and translational outlook In addition to their mechanistic implications, the immune pathways discussed throughout this review have increasingly emerged as actionable therapeutic targets in PD

These options underscore that while Epitalon remains experimental, practical interventions for extending healthspan are available today