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These results are transformative, often involving the loss of 50 to 100+ pounds depending on starting weight
Specifically, semaglutide may decrease activity in the hypothalamus, a brain region that controls appetite, and increase activity in the mesolimbic reward system, which regulates food intake and cravings
If pregnancy is planned, the medication should be discontinued at least two months before attempting conception due to the long washout period of semaglutide
Many studies have highlighted the role of dysbiosis in obesity [48, 49], with some studies indicating it could be modulated by several months on an LFD [50, 51]
PloS Pathog (2020) 16(6):e1008627
doi:10.5603/GP.a2020.0173
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