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WHO SHOULD NOT TAKE IT, AND WHO NEEDS EXTRA CARE EVIDENCE The weight-management evidence for semaglutide comes from the STEP trial programme, and its cardiovascular evidence comes from the SELECT trial
No Known Major Side Effects Well-tolerated and naturally occurring in the body
Compounded injectable semaglutide typically offers bioavailability comparable to brand formulations while oral semaglutide requires higher doses due to GI absorption limitations, affecting cost and convenience trade-offs
Instead, several overlapping mechanisms may contribute
503A pharmacies and physicians: Prohibited from compounding, distributing, or dispensing tirzepatide after February 18, 2025
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