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Subsequently, oral formulations and once weekly injections were developed in the 2010s and liraglutide was the first GLP-1 receptor agonist approved for the treatment of obesity in 2014

[Melatonin synthesis in enterochromaffin cells] [PMID: 1259609] Laboratory literature summary: [Melatonin synthesis in enterochromaffin cells]

Diabetologia (2013) 56(5):96572

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Then in May 2025, the first direct head-to-head trial SURMOUNT-5 was published in the New England Journal of Medicine , putting the two medications head-to-head in the same patients, at the same time, under the same conditions