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Bajaj H, Welch M, Shah P et al
The trial established the IGF-1 axis as a clinical therapeutic target and supports the broader pharmacological rationale for IGF-1 receptor agonism, of which IGF-1 LR3 is one analog with extended pharmacokinetic properties
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taken on empty stomach for oral Safety Comparison# STEP 8 Head-to-Head Safety# In the STEP 8 trial, overall adverse event rates were similar (semaglutide 95.2% vs liraglutide 96.1%), but discontinuation rates were notably different: The substantially lower discontinuation rate with semaglutide (3.2% vs 12.6%) suggests better tolerability despite greater pharmacological effect
