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As well see later when we go into the data, this still is not a magic shot - its worth noting that it still takes nearly a year for these outcomes to happen (and likely many patients will be n maintenance doses as they continue to lose weight beyond those timeframes)
[5] Wang, Y., Zhao, L., Gao, L., Pan, A., & Xue, H
The results were mixed, at best
Furthermore, smaller clinical trials as well as pre-clinical studies have provided some, albeit not conclusive, support for the clinical outcomes-based evidence of the benefit of GLP-1 RAs in HF
GLP-1 receptor agonists enhance glucose-dependent insulin secretion and promote satiety, whilst SGLT2 inhibitors block renal glucose reabsorption causing urinary glucose excretion
Deep Dive: The GLP-1 Impact Background: Starting Tirzepatide (April 2024) In April 2024, I started Tirzepatide (Mounjaro/Zepbound) at 2.5mg, gradually escalating to 10mg over several months
