Food and Drug Administration (FDA) approved aducanumab as the first disease-modifying therapy (DMT) for AD in June 2021, 10 there has been considerable medical and scientific controversy regarding its curative effect
GHK-Cu products typically show visible firming and tone improvement at 8 to 12 weeks of daily use
In contrast, long acting GLP-1 receptor agonists have relatively little effect on the rate of gastric emptying due to the development of tachyphylaxis resulting from continuous activation of the GLP-1 receptors in the GI tract (Nauck et al, 2011
Research has shown that GLP-1 may be beneficial for patients with hidradenitis suppurativa , particularly through its combined effects on weight loss and inhibition of inflammatory pathways
but upon activation due to endothelial injury, they facilitate renal artery thrombosis by initiating the blood coagulation cascade through the synthesis of procoagulant factors that enhance the generation and spread of thrombin [88]
A balanced approach that includes both is ideal