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The constraint is tolerability: greater potency brings more gastrointestinal burden during titration, which is why the engineering of dose escalation now matters as much as efficacy
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Small, frequent sips may be better tolerated than large volumes at once, particularly if nausea is present
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A sterile 10 L pipette tip was used to create wounds, and areas of wound lines were observed and assessed by inverted microscope after 24 h
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