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Yet, results from another two-year, randomized controlled trial the T reatment O f N onalcoholic fatty liver disease I n C hildren (TONIC) in 173 children (ages, 8-17 years) with MAFLD failed to observe any significant reduction in blood concentrations of alanine and aspartate aminotransferases either with supplemental vitamin E (536 mg/day of RRR --tocopherol) or with metformin (an anti-diabetic drug