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(1) Released in eight to 10 pulses per 24-hour period, peak release of the hormone occurs while we sleep with short pulses throughout the day

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10.1002/ajh.10321 Am

Melatonin treatment suppressed inflammatory mediators such as interleukin-1 and NO, decreased superoxide production in the aorta, and mitigated polymorphonuclear neutrophil (PMN) infiltration in the lungs and liver (Wu et al., 2008)