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For SC injections, the medication is placed in the soft, fatty tissue directly beneath the skin, with the needle angled at roughly 45 degrees
Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity
Post-injection skin inflammation and infections may occur due to unsanitary administration or a reaction to the medicine
Useful target-engagement readouts may include reduced 1-methylnicotinamide formation, changes in nicotinamide-related metabolites, and confirmation that the selected cellular or tissue model expresses NNMT at a level relevant to the experimental question
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Take baseline photographs at the start and comparison photographs at the four and six week marks
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