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Early evidence suggests these medications may actually improve quality of life and mood in patients with obesity, without increasing depression or suicidal ideationconcerns that have plagued older weight-loss medications
Appetite & Energy Research MT-IIs activation of MC4R has drawn interest in appetite regulation research
As Hemmi notes: Some people will lose access. In an emailed statement to WIRED, a spokesperson for Novo Nordisk says, Moving forward, any compounder that mass produces or sells knockoff drugs is breaking the law and compromising patient safety. A spokesperson for Eli Lilly echoed that sentiment, saying via email that the FDA and a federal court have both made clear that compounders must cease production of compounded tirzepatide knockoffs. Anthony Comuzzie, CEO of the Obesity Society, recognizes that there are legitimate access issues to GLP-1 medications, but he worries that some people who have sought out compounded versions may not meet the medical definition of obesity and are using them more casually for weight loss
Gastroenterology 2022
Structured systematic review procedures were conducted to synthesize updated evidence on the cost-effectiveness of GLP-1RAs versus insulin
There is no scientific evidence that drinking tap water directly increases GLP-1 levels
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