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That conclusion does not require overstating the evidence
HUBERMAN: Things that are associated with the transition from winter to spring and summer months in humans and in other animals
These processes involve the activation of muscarinic cholinergic receptors in the forebrain, and an increased expression of type-2 metabotropic glutamate (mGlu2) receptors in dorsal root ganglia neurons
It is usually harmless, but for cosmetic reasons, it is a nuisance to those who have it
doi:10.1016/j.neubiorev.2015.04.015
Very high concentrations or excessive application frequency are more likely to trigger irritation without a proportional benefit, and the dose-response relationship for cosmetic GHK-Cu is not precisely defined in the literature
