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PARKINSON'S DISEASE The brains of patients with Parkinson's disease exhibited a reduction of GSH, selective to the substantia nigra (SN)
Jan-Feb 2016;16(1):2-7
93 ColemanM
The most extensively documented involves upregulation of vascular endothelial growth factor (VEGF) and its receptor VEGFR2, promoting angiogenesis, the formation of new blood vessels, in injured tissue
The enzyme glutathione reductase, which is quite active in red blood cells, carries out this reduction, using NADPH as a reducing agent
IGF-1 acts as a neurotrophic factor in the brain, contributing to the growth of new brain cells and the survival of existing neurons
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