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Aging is defined here as an organism-level, progressive functional and systemic process characterized by gradual changes in physiological resilience and homeostatic regulation across the lifespan ( Throughout this review, these constructs are addressed according to the level of evidence discussed: organismal aging in relation to circadian rhythm alterations and sleep architecture

[6] Release of GST-A1 as an indication of cellular necrosis [edit] Increases in serum and urinary GST-A1 have been found in association with hepatocyte and renal proximal tubular necrosis respectively, and have potential for monitoring injury to these tissues

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For optimal effectiveness, these injections should be taken regularly over time rather than in single large doses