Semaglutide may be a good option due to the effectiveness shown in studies
Wait a full 30 minutes before eating, drinking other beverages, or taking other medicationsdoing otherwise may reduce absorption
A 2023 SELECT trial determined that patients with pre-existing cardiovascular disease who used Wegovy over 39.8 months experienced the following events, compared to patients given a placebo

Food Choices: What to Favor and What to Avoid Grilled chicken breast, turkey Fish and seafood (salmon, cod, shrimp) Eggs and egg whites Greek yogurt and cottage cheese Beans, lentils, and legumes Lean beef (sirloin, 93% ground) Protein shakes (when appetite is suppressed) Leafy greens: spinach, kale, romaine Broccoli, cauliflower, Brussels sprouts Whole grains: brown rice, quinoa, oats Chia seeds (fiber + protein in small portions) Apples, pears, berries Beans and legumes (fiber + protein) Avocado Olive oil Nuts and seeds Fatty fish (salmon, mackerel) Sodas and sweetened drinks Fruit juices and sports drinks Sweetened coffee drinks Candy, pastries, flavored yogurt Packaged snack foods with added sugar Fried foods (worsens nausea significantly) Fast food Fatty processed meats Chips, crackers, refined snack foods White bread, white pasta, white rice Alcohol (amplifies GI side effects) Spicy or highly acidic foods Large, heavy meals High-fat, high-sodium fast food Unsaturated fats from olive oil, avocado, and fatty fish may support GLP-1 secretion and provide important fat-soluble vitamins (A, D, E, K)

Some people ended up in the hospital, though many symptoms resolved after IV fluids and anti-nausea medication
Dehydration: Reduced appetite and fluid intake can lead to dehydration, causing muscle cramps and soreness