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Study findings The study cohort consisted of 36,082 and 234,028 GLP-1 receptor agonist and DPP-4 inhibitor users, respectively, who were followed for a median of 1.3 and 1.7 years

Adding amylin agonism to a dual or triple incretin agonist is mechanistically plausible, but the concern is stacked gastrointestinal burden: adding semaglutide alone pushed GI events from 54.0% to 79.6%, and discontinuations from 2.6% to 5.9%

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GLP-1 RAs, such as semaglutide and tirzepatide, may also help improve metabolic health in patients with PCOS by promoting weight loss, improving insulin sensitivity, and reducing blood glucose levels ( 4 , 6 , 14 )

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However, several key considerations must inform their clinical application