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Qiu, Y., Huang, J
As a consequence of iron overload, dysplastic changes and detrimental effects on erythroblast differentiation and maturation resulting in a reduction of the proliferative capacity of erythropoiesis and of erythroblast apoptosis in vitro have been described ( via ROS-mediated activation of p38MAPK, JNK and p53 pathways in immature hematopoietic cells ( Elevated Iron Levels in MDS and AML Patients Measurement of a patients iron status is difficult due to various pitfalls of the available methods
have found that during MMP, p62 may induce autophagy by binding to the ubiquitinated VDAC1 protein localized on the OMM [278]
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It can be treated with vitamin B12 medications
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